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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
21.52
Human Site:
S323
Identified Species:
33.81
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
S323
S
S
P
S
A
P
A
S
D
S
I
G
P
Q
I
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
S323
S
S
P
S
A
P
A
S
D
S
I
G
P
Q
I
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
T292
S
P
G
P
P
I
L
T
S
P
S
P
S
K
S
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
D307
S
S
S
A
P
P
S
D
S
T
G
P
Q
I
L
Rat
Rattus norvegicus
P11345
648
72910
T242
P
H
A
F
T
F
N
T
S
S
P
S
S
E
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
S303
S
S
P
S
A
T
P
S
D
S
I
G
P
P
I
Chicken
Gallus gallus
Q04982
806
89347
S323
S
Y
P
S
V
P
P
S
D
S
V
G
P
P
I
Frog
Xenopus laevis
P09560
638
71941
T232
S
S
Q
Q
R
Y
S
T
P
H
P
F
S
F
S
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
S333
M
C
P
S
L
P
P
S
E
S
T
G
S
L
C
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
S333
V
C
P
S
L
P
P
S
D
S
T
G
S
I
C
Fruit Fly
Dros. melanogaster
P11346
782
88616
S347
A
V
R
F
N
M
S
S
R
S
R
S
R
R
C
Honey Bee
Apis mellifera
XP_396892
715
80060
S300
R
N
Q
R
H
P
R
S
L
G
Q
Q
D
R
S
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
P360
S
T
Q
A
R
H
R
P
H
F
Q
S
G
H
I
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
P319
S
S
D
D
Q
D
F
P
R
N
T
L
P
R
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
V353
V
P
I
G
S
L
S
V
G
L
C
R
H
R
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
6.6
N.A.
20
6.6
N.A.
80
66.6
13.3
40
46.6
13.3
13.3
13.3
20
P-Site Similarity:
100
100
N.A.
20
N.A.
46.6
20
N.A.
80
73.3
26.6
46.6
46.6
33.3
26.6
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
14
20
0
14
0
0
0
0
0
0
0
7
% A
% Cys:
0
14
0
0
0
0
0
0
0
0
7
0
0
0
20
% C
% Asp:
0
0
7
7
0
7
0
7
34
0
0
0
7
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
7
% E
% Phe:
0
0
0
14
0
7
7
0
0
7
0
7
0
7
0
% F
% Gly:
0
0
7
7
0
0
0
0
7
7
7
40
7
0
7
% G
% His:
0
7
0
0
7
7
0
0
7
7
0
0
7
7
0
% H
% Ile:
0
0
7
0
0
7
0
0
0
0
20
0
0
14
34
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% K
% Leu:
0
0
0
0
14
7
7
0
7
7
0
7
0
7
7
% L
% Met:
7
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
7
0
7
0
0
7
0
0
0
0
0
% N
% Pro:
7
14
40
7
14
47
27
14
7
7
14
14
34
14
0
% P
% Gln:
0
0
20
7
7
0
0
0
0
0
14
7
7
14
0
% Q
% Arg:
7
0
7
7
14
0
14
0
14
0
7
7
7
27
0
% R
% Ser:
60
40
7
40
7
0
27
54
20
54
7
20
34
0
20
% S
% Thr:
0
7
0
0
7
7
0
20
0
7
20
0
0
0
0
% T
% Val:
14
7
0
0
7
0
0
7
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _